N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Names and Identifiers

Name	Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester
Synonyms	Dabigatran (ethyl ester) Ethyl 3-(2-((4-carbaMiMidoylphenylaMino)Methyl)-1-Methyl-N-(pyridin-2-yl)-1H-ben ethyl 3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoat Ethyl 3-(2-((4-carbaMiMidoylphenylaMino)Methyl)-1-Methyl-N-(pyridin-2-yl)-1H-benzo[d]iMidazole-5-carboxaMido)propanoate Alanine, N-[[2-[[[4-(aMinoiMinoMethyl)phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester ethyl 3-(2-((4-carbamimidoylphenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate hydrochloride
CAS	429658-95-7
EINECS	695-000-6

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Physico-chemical Properties

Molecular Formula	C27H29N7O3
Molar Mass	499.58
Density	1.31
Boling Point	759.5±70.0 °C(Predicted)
pKa	12.92±0.50(Predicted)
Storage Condition	2-8℃
MDL	MFCD16294325

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Preparation solution concentration reference

	1mg	5mg	10mg
1 mM	2.002 ml	10.008 ml	20.017 ml
5 mM	0.4 ml	2.002 ml	4.003 ml
10 mM	0.2 ml	1.001 ml	2.002 ml
5 mM	0.04 ml	0.2 ml	0.4 ml

Last Update：2024-01-02 23:10:35

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Reference Information

Use	Dabidadhern ethyl ester is a synthetic intermediate of dabidadhern ester. At present, there are many documents and patents that introduce the synthesis methods of dabygatetexilate. In these synthesis routes, most of the p-toluenesulfonate of dabygatetexilate is used as an important intermediate. Dabitran etexilate is a new oral anticoagulant developed by Germany Boehringer Ingelheim Company, which belongs to non-peptide thrombin inhibitor. The drug was approved for marketing in Europe in April 2008.
preparation	5g of 3 is dissolved in 50ml of mixed solvent of toluene and chloroform (volume ratio of toluene to chloroform 1:2), stirred and dissolved, then 3ml of anhydrous ethanol is added, and dry hydrogen chloride gas is introduced at 10 ℃, the weight gain of the system is 7.7g, and ventilation is stopped. Heat preservation, stirring and reaction for 24 hours, evaporation and drying under reduced pressure to obtain oil substance I; Dissolve the oil substance I with 30ml of absolute ethanol, then raise the temperature to 35 ℃, add 10g of ammonium carbonate, stir for 12 hours, add 20ml of saturated potassium carbonate solution, continue stirring for 0.5 hours, filter, scrub the filter cake with ethanol, and evaporate the filtrate to dry under reduced pressure to obtain oil substance II. Dissolve the oil substance II with 30ml of tetrahydrofuran aqueous solution (the volume ratio of tetrahydrofuran to water is 1:0.5), add 2.6g of p-toluenesulfonic acid, add 15ml of 25% ammonia water dropwise, and the precipitated solid is 1. Filter, after washing with water, vacuum drying at 60 ℃ to obtain 1, mesylate of dabigatran ethyl ester with a yield of 92.4%, and the purity is 97.7% by HPLC detection.
biological activity	Dabigatran ethyl ester is a new oral anticoagulant compound and thrombin inhibitor.

Last Update：2024-04-09 02:00:08

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester

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Product Name: Dabigatran ethyl AcOH Salt Request for quotation
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Hubei YoungXin Pharmaceutical Tech Co.,Ltd.

Spot supply

Product Name: Dabigatran Impurity 16 Visit Supplier Webpage Request for quotation
CAS: 429658-95-7
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

Wechat: 15671228036

Shanghai Yuanye Bio-Technology Co., Ltd.

Wechat: 18301782025

Wuhan Boye Science And Technology Development Co., Ltd.

Product Name: Dabigatran ethyl AcOH Salt Request for quotation
CAS: 429658-95-7
Tel: 86-10-10086 81625225
Email: yeqim@boyechemicals.com
Mobile: 86-15387090420
QQ: 1377812380

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N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester

Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester

CAS: 429658-95-7

Molecular Formula: C27H29N7O3

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Names and Identifiers

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Physico-chemical Properties

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Preparation solution concentration reference

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Reference Information

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N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester Request for Quotation

Alanine, N-[[2-[[[4-(aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester

CAS: 429658-95-7

Molecular Formula: C27H29N7O3

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Names and Identifiers

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Physico-chemical Properties

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Preparation solution concentration reference

N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester - Reference Information

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N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester